ALPS Medical Breakthroughs ETF
ALTAR
Score™		 -1.5% info Recommen-
dation		 AVOID
2020E    2021E
P/E
ratio		 -9.2x P/Sales
ratio		 8.9x
P/BV
ratio		 9.3x Div.
yield		 0.0%


  • Description
  • Performance
  • Comps
  • premium Fundamentals
  • premium Valuation
  • premium Rating
ALPS Medical Breakthroughs ETF is an exchange-traded fund incorporated in the USA. The ETF seeks investment results that correspond generally to the performance of its underlying index, the Poliwogg Medical Breakthroughs Index (ticker symbol: PMBI).

FUND BASICS
Category US Equities
Fund Sponsor ALPS Advisors Inc
Website www.alpsetfs.com
Inception date Dec 30, 2014
Assets (mns) $147
Currency USD
Expense ratio 50 bp
Distributions Annually

FUND STRUCTURE
Regulation Open-Ended Fund
Custodian Bank of New York Mellon
Weighting Market Cap
Index replication Full
Uses derivatives No
Options available Yes

SECTOR BREAKDOWN

 


CONSTITUENT BREAKDOWN
No. of constituents 69
Wgt avg mkt cap (mns) $1,675
Large cap (>$10bn) 0.0%
Mid cap ($2-10bn) 51.4%
Small cap (<$2bn) 48.6%
Developed mkts 100.0%
Emerging mkts 0.0%

TOP TEN HOLDINGS
ACCELERON PHARMA INC 5.1 %
UNITED THERAPEUTICS CORP 4.8 %
MIRATI THERAPEUTICS INC 3.9 %
MORPHOSYS AG SPONSORED ADR 3.7 %
GLOBAL BLOOD THERAPEUTICS INC 3.6 %
FIBROGEN INC 3.6 %
IMMUNOMEDICS INC 3.3 %
PTC THERAPEUTICS INC 3.2 %
BLUEBIRD BIO INC 3.0 %
CHEMOCENTRYX INC 2.8 %
Total 36.9 %

TOP COUNTRY EXPOSURE
UNITED STATES 73.2 %
GERMANY 3.7 %
IRELAND 2.7 %
NETHERLANDS 2.4 %







HISTORICAL PERFORMANCE info

  Custom date range Compare to  
  thru


Standardized Annual Returns (thru March 31)
Year-to-date 1 year 5 years 10 years Since Incep.
-25.0% -12.4% 2.1% -- 5.7%

Market Correlations
versus... Beta R-squared
S&P500 1.33 52%
MSCI EAFE 1.17 39%
MSCI Emg. Mkts. 0.98 40%

Technical Indicators
Recent close $30.35
30d moving avg. $34.34
Annualized volatility 28.0%
Short interest (ETF) 0.2%
Short interest (Underlying) 10.6%
Relative strength (RSI) 35

Liquidity measures
Avg. volume (thou.) 99
Turnover 2.0%
Bid/Ask (% of price) 0.75%
ADV underlying (mns) $1,155

Distributions


FINDING ALTERNATIVE FUNDS

Below is a list of 100 potential alternatives to the ALPS Medical Breakthroughs ETF ETF based on the alternatives' overlap in portfolio holdings with SBIO. Consider funds with lower expense ratios and/or higher ALTAR Score™ ratings as possible alternatives.

Benchmark ticker: SBIO Expense: 50 bp ALTAR Score™: -1.5%


ALTERNATIVE ETFs BASED ON OVERLAP WITH SBIO
Ticker Fund
Name		 Overlap1
vs SBIO
(%)		 Expense
ratio
(bp)		 Savings
vs SBIO
(bp)		 ALTAR
Score™
(%)		 ALTAR
vs SBIO
(%)
XBI SPDR S&P BIOTECH ETF 26.2 35 15 -5.3 -3.8
BBC Virtus LifeSci Biotech Clinical Trials ETF 21.6 79 -29 0.0 +1.5
PBE Invesco Dynamic Biotechnology & Genome ETF 18.2 57 -7 -1.1 +0.4
BTEC Principal Healthcare Innovators Index ETF 17.8 42 8 -5.2 -3.8
IDNA iShares Genomics Immunology & Healthcare ETF 16.3 47 3 -3.6 -2.1
FBT First Trust NYSE Arca Biotechnology Index Fund 13.7 57 -7 -0.2 +1.3
PTH Invesco DWA Healthcare Momentum ETF 11.4 60 -10 -4.3 -2.8
GNOM Global X Genomics & Biotechnology ETF 11.0 68 -18 -3.8 -2.3
IBB iShares NASDAQ Biotechnology ETF 8.4 47 3 0.8 +2.3
CNCR Loncar Cancer Immunotherapy ETF 7.7 79 -29 -4.8 -3.4
HELX Franklin Genomic Advancements ETF 6.2 50 0 -2.3 -0.8
FYC First Trust Small Cap Growth AlphaDEX Fund 4.9 70 -20 3.7 +5.2
IWO iShares Russell 2000 Growth ETF 4.8 24 26 1.6 +3.0
VTWG Vanguard Russell 2000 Growth Index Fund 4.7 15 35 1.8 +3.3
MFMS Motley Fool Small-Cap Growth ETF 4.7 85 -35 -2.2 -0.7
FTXH First Trust Nasdaq Pharmaceuticals ETF 4.6 60 -10 7.9 +9.3
IEIH iShares Evolved U.S. Innovative Healthcare ETF 4.5 18 32 4.5 +6.0
GDNA Goldman Sachs Motif Human Evolution ETF 4.3 50 0 0.6 +2.0
JKK iShares Morningstar Small-Cap Growth ETF 4.2 30 20 2.3 +3.7
IWC iShares Micro-Cap ETF 4.1 60 -10 -5.5 -4.0
VALX Validea Market Legends ETF 3.8 79 -29 19.3 +20.8
DWAS Invesco DWA SmallCap Momentum ETF 3.7 60 -10 1.1 +2.5
IWM iShares Russell 2000 ETF 3.0 19 31 5.7 +7.1
VTWO Vanguard Russell 2000 Index Fund 2.9 10 40 5.8 +7.3
PQSG PGIM QMA Strategic Alpha Small-Cap Growth ETF 2.9 29 21 0.0 +1.5
JHSC John Hancock Multifactor Small Cap ETF 2.8 50 0 8.6 +10.0
RYJ Invesco Raymond James SB-1 Equity ETF 2.7 82 -32 5.1 +6.6
MJ ETFMG Alternative Harvest ETF 2.5 75 -25 -6.5 -5.0
CNBS Amplify Seymour Cannabis ETF 2.5 75 -25 -16.2 -14.8
YOLO AdvisorShares Pure Cannabis ETF 2.5 74 -24 -28.7 -27.3
FYX First Trust Small Cap Core AlphaDEX Fund 2.5 63 -13 9.1 +10.5
SCHA Schwab U.S. Small-Cap ETF 2.4 4 46 7.5 +8.9
VBK Vanguard Small-Cap Growth Index Fund 2.2 7 43 3.9 +5.4
PBSM Invesco PureBeta MSCI USA Small Cap ETF 2.1 6 44 8.0 +9.5
NUSC Nuveen ESG Small-Cap ETF 2.1 40 10 7.6 +9.0
ARKG ARK Genomic Revolution Multi-Sector ETF 2.0 75 -25 -26.8 -25.4
PDP Invesco DWA Momentum ETF 2.0 62 -12 4.4 +5.9
SQLV Legg Mason Small-Cap Quality Value 1.9 62 -12 12.2 +13.7
AFSM First Trust Active Factor Small Cap ETF 1.9 75 -25 10.6 +12.1
SCAP AdvisorShares Cornerstone Small Cap ETF 1.9 90 -40 8.1 +9.5
USVM VictoryShares USAA MSCI USA Small Cap Value Momentum ETF 1.9 24 26 11.1 +12.6
ESML iShares MSCI USA Small-Cap ESG Optimized ETF 1.9 17 33 7.3 +8.7
GURU Global X Guru Index ETF 1.9 75 -25 5.6 +7.0
VFMO Vanguard U.S. Momentum Factor ETF 1.9 13 37 4.7 +6.2
BBH VanEck Vectors Biotech ETF 1.8 35 15 4.5 +5.9
PSC Principal U.S. Small Cap Index ETF 1.7 38 12 11.1 +12.5
FNY First Trust Mid Cap Growth AlphaDEX Fund 1.7 70 -20 4.5 +6.0
GSSC Goldman Sachs Activebeta U.S. Small Cap Equity ETF 1.5 20 30 9.7 +11.2
JKL iShares Morningstar Small Cap Value ETF 1.5 30 20 14.8 +16.3
SMDY Syntax Stratified MidCap ETF 1.4 30 20 9.1 +10.6
ISMD Inspire Small/Mid Cap Impact ETF 1.4 61 -11 7.6 +9.1
PJP Invesco Dynamic Pharmaceuticals ETF 1.4 56 -6 12.5 +13.9
VXF Vanguard Extended Market Index Fund 1.4 7 43 5.9 +7.4
FAD First Trust Multi Cap Growth AlphaDEX Fund 1.4 66 -16 4.2 +5.7
VB Vanguard Small-Cap ETF 1.4 5 45 8.1 +9.6
JKJ iShares Morningstar Small-Cap ETF 1.3 25 25 9.0 +10.5
VHT Vanguard Health Care Index Fund 1.3 10 40 6.5 +8.0
FHLC Fidelity MSCI Health Care Index ETF 1.3 8 42 6.6 +8.1
IHE iShares U.S. Pharmaceuticals ETF 1.2 42 8 6.5 +8.0
BOSS Global X Founder-Run Companies ETF 1.1 45 5 4.8 +6.2
PSCH Invesco S&P SmallCap Health Care ETF 1.1 29 21 4.2 +5.7
DWMC AdvisorShares Dorsey Wright Micro-Cap ETF 1.1 125 -75 -2.9 -1.4
RFG Invesco S&P Midcap 400 Pure Growth ETF 1.1 35 15 6.0 +7.5
ROGS Hartford Multifactor Global Small Cap ETF 1.1 34 16 11.7 +13.2
JPSE JPMorgan Diversified Return U.S. Small Cap Equity ETF 1.0 29 21 8.5 +10.0
XT iShares Exponential Technologies ETF 0.9 47 3 6.8 +8.2
VFLQ Vanguard U.S. Liquidity Factor ETF 0.8 13 37 5.5 +7.0
IWN iShares Russell 2000 Value ETF 0.8 24 26 10.3 +11.8
LNGR Global X Longevity Thematic ETF 0.8 50 0 4.4 +5.9
VTWV Vanguard Russell 2000 Value Index Fund 0.8 15 35 10.5 +11.9
AVUV Avantis U.S. Small Cap Value ETF 0.8 25 25 13.8 +15.3
PRFZ Invesco FTSE RAFI US 1500 Small-Mid ETF 0.8 39 11 6.4 +7.8
FSMD Fidelity Small-Mid Factor ETF 0.7 29 21 9.9 +11.4
JHMH John Hancock Multifactor Healthcare ETF 0.7 40 10 7.2 +8.6
FNX First Trust Mid Cap Core AlphaDEX Fund 0.7 61 -11 10.1 +11.6
IJJ iShares S&P Mid-Cap 400 Value ETF 0.7 25 25 12.0 +13.4
MDYV SPDR S&P 400 Mid Cap Value ETF 0.7 15 35 12.1 +13.5
IVOV Vanguard S&P Mid-Cap 400 Value ETF 0.7 15 35 12.2 +13.7
PQSV PGIM QMA Strategic Alpha Small-Cap Value ETF 0.7 29 21 12.6 +14.1
KOMP SPDR Kensho New Economies Composite ETF 0.7 20 30 2.8 +4.3
TECB iShares US Tech Breakthrough Multisector ETF 0.7 40 10 5.4 +6.9
EWMC Invesco S&P MidCap 400 Equal Weight ETF 0.6 40 10 9.7 +11.2
SFYX Sofi Next 500 ETF 0.6 0 50 8.2 +9.6
ONEQ Fidelity Nasdaq Composite Index Tracking Stock 0.6 21 29 4.4 +5.8
TUSA First Trust Total US Market AlphaDEX ETF 0.6 70 -20 9.4 +10.8
RZG Invesco S&P Smallcap 600 Pure Growth ETF 0.6 35 15 9.8 +11.2
VBR Vanguard Small Cap Value Index Fund 0.6 7 43 12.0 +13.5
IPO Renaissance IPO ETF 0.5 60 -10 -13.2 -11.8
FLQS Franklin LibertyQ U.S. Small Cap Equity ETF 0.5 35 15 9.1 +10.6
SCHM Schwab U.S. Mid-Cap ETF 0.5 4 46 9.0 +10.5
VUSE Vident Core US Equity Fund 0.5 48 2 11.0 +12.4
SMMV iShares Edge MSCI Min Vol USA Small-Cap ETF 0.5 20 30 7.8 +9.3
IUSS Invesco Strategic US Small Company ETF 0.5 23 27 9.0 +10.4
IYH iShares U.S. Healthcare ETF 0.5 43 7 7.1 +8.6
ITEQ BlueStar Israel Technology ETF 0.4 75 -25 2.9 +4.4
IZRL ARK Israel Innovative Technology ETF 0.4 49 1 -0.9 +0.6
IVOO Vanguard S&P Mid-Cap 400 ETF 0.4 10 40 9.0 +10.5
MDY SPDR S&P Midcap 400 ETF Trust 0.4 23 27 8.9 +10.4
VFQY Vanguard U.S. Quality Factor ETF 0.4 13 37 8.5 +10.0
IJH iShares Core S&P Mid-Cap ETF 0.4 6 44 9.1 +10.5

1Overlap is the percentage of holdings by weight that are identical. For example, if Fund A has a 2% position in Apple, Inc. (AAPL) and Fund B has a 5% position, their overlapping position in AAPL is 2%.

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RESULTS & ESTIMATES

  2015 2016 2017 2018 2019 2020E 2021E
Sales per share ** ** ** ** ** ** **
Earnings per share ** ** ** ** ** ** **
Dividends per share info ** ** ** ** ** ** **
Book value per share ** ** ** ** ** ** **

 

Sales per share growth   **% **% **% **% **% **%
EPS growth   **% **% **% **% **% **%

Sales per share growth   **% **% **% **% **% **%
EPS growth   **% **% **% **% **% **%

OTHER FUNDAMENTAL METRICS

Long term EPS growth est. **%   Debt-to-equity **x
Asset turnover **%   Assets-to-equity **x

Return on equity

Revision activity*
*Six months ago = 100

Net margins

Compound annual growth rates

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VALUATION METRICS
  2019 2020E 2021E
Price-to-sales ** ** **
Price-to-earnings ** ** **
Price-to-cash flow ** ** **
Price-to-growth ** ** **
Price-to-book value ** ** **
Yield ** ** **

Historical valuation trends

Forward
multiple:		 ALPS Medical Breakthroughs ETF
Relative
to:		 S&P500 MSCI EAFE MSCI Emg. Mkts. Other ETF:

AVOID
Not worthwhile for most investors. A rating of AVOID is assigned to ETFs with ALTAR Scores in the lowest quintile (the bottom 20%) of their category. Often, funds in this category consist of stocks with little if any history or expectation of profitability, and as a result our fundamentally-driven analysis may not be relevant.

ALTAR Score™


Calculation of ALTAR Score™
Avg. Return on Equity -56.8 %
Divided by: Fwd. P/BV 58.9 x
Less: Expense ratio 50 bp
Equals: ALTAR Score -1.5 %
info More information on ALTAR Score™
MODERN PORTFOLIO THEORY info

CONSENSUS RECOMMENDATIONS: FUND CONSTITUENTS
COMPOSITE
RATING		 1.29 CATEGORY
AVERAGE		 1.51
 
The composite rating is a weighted average of analysts' consensus recommendations for individual ETF constituents, based on the following scale:

BUY = 1; OVERWEIGHT = 1.5, HOLD = 2; UNDERWEIGHT = 2.5; and SELL = 3.

Readers are cautioned that because analyst ratings tend to be inflated, the composite score may be more useful as a relative measure of sentiment between funds rather than as a stand-alone recommendation.
 

 

See RATING tab for calculation of ALTAR Score™
Risk & reward. Uses std. dev. as proxy for risk, ALTAR Score™ for return forecast.
Dividends paid by constituents to the fund. May differ from actual distributions to shareholders due to constituent changes, timing issues or other factors.
Monthly returns based on changes in price plus dividends. May differ from daily returns reported by funds. See below for standardized returns.